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‘Zits was debilitating for me so I arrange a £40m enterprise to assist others’

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Last updated: January 4, 2026 6:18 am
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James Mishreki started as a professional poker player before turning to health tech. James Mishreki began as an expert poker participant earlier than turning to well being tech.

James Mishreki suffered from zits as an adolescent rising up in Northumberland. A debilitating interval which dented his confidence, he was nicknamed ‘pizza face’ for a 12 months as he went via NHS therapies. It then returned in his 20s and led to a different spherical of medicines.

When it got here to the entrepreneur co-founding dermatology service Pores and skin + Me in 2018, Mishreki “knew how badly individuals wished to do away with zits”. In 4 years, the British agency, which offers pores and skin therapy on prescription-grade subscriptions, accrued close to £40m revenues since launch in 2020.

“I grew to become fascinated within the skincare trade, this £140bn trade with 55% buyer dissatisfaction,” he says. “I knew what it was wish to undergo the zits journey and it’s not like you possibly can speak to your dermatologist frequently.”

Learn Extra: We made 25 jars at a time – now our enterprise boasts a world’s greatest marmalade

We first speak via Mishreki’s early profession, which comprised two years of taking part in poker professionally after finishing his advertising and marketing administration research at Northumbria College in 2008.

Having tinkered with a number of web-based startups, co-founding retail intelligence outfit Aggressive Monitor led to him quitting poker full-time to hitch the booming e-commerce sector.

An concept was solid on scraping web sites which might index and bundle to clients together with John Lewis, which might use its info software program to maintain tabs on rivals’ pricing.

Skin + Me The Pores and skin + Me co-founder has a novel philosophy on ‘rejection coaching’.

For an extended interval Mishreki paid himself £500 monthly, however as one of many first movers the corporate didn’t double down on being enterprise first or elevating non-public fairness. “We ended up competing with bed room operators in Russia and being undercut on worth,” he admits.

After efficiently exiting in 2018, Mishreki labored with co-founder Philip Wilkinson in organising a personalised skincare suggestion service referred to as Mr & Mrs Oliver, primarily to check what shoppers valued and wished.

Mishreki ventured to House NK and Debenhams the place he would chat to skincare advisors and ask in the event that they wished to earn more money engaged on his startup.

Customers had been despatched a therapy field for his or her pores and skin objectives and the founders discovered that individuals positioned excessive worth on having credible specialists reviewing consultations and making suggestions.

Mishreki admits the enterprise mannequin was “flawed”. Delivery third social gathering skincare merchandise, shoppers would then discover cheaper manufacturers elsewhere. Nevertheless, the founders’ aim to construct a personalised regime had been born, which proved a fancy operation to arrange.

The company only uses real Skin + Me community members in its marketing. The corporate solely makes use of actual Pores and skin + Me group members in its advertising and marketing.

Pores and skin + Me needed to construct a regulatory-approved pharmacy, arrange personalisation know-how for prescriptions and create a model “individuals liked and trusted”. In the meantime, the founders set about in search of expert consultants by sending over 200 handwritten letters to a 3rd of the UK’s dermatologists.

Story Continues

Mishreki additionally has a novel tackle what he refers to as ‘rejection coaching’ as he sought to accumulate funding.

Learn Extra: ‘Our girls’s climbing trousers saved our enterprise – we have offered over 50,000’

“Rejection is an efficient factor on the subject of being an entrepreneur,” he says. “The earlier you get a number of rejections underneath your belt the earlier you cease caring and satirically the extra you get, the much less it occurs.”

After an exhausting pursuit knocking on investor doorways, the founders modified tact after initially on the lookout for £50,000 funding. They now regarded to lift significant capital to construct to scale from the get go and so they quickly acquired £8m seed funding.

“All the pieces goes improper on a regular basis. If I anticipate a no, it’s a possibility to study and get higher. It was a bonus if I received a ‘sure’.

“The market does not care about your emotions. It has been extremely tense constructing the corporate however I’m tremendous proud. The UK inhabitants is a lot better off getting access to this service.”

⁠In five years, James Mishreki took Skin +Me to £37m revenue. James Mishreki took Pores and skin +Me to £37m income in simply over 5 years.

London-based Pores and skin + Me went to market with 20 employees. There are actually over 150 staff, with an workplace in Paddington and an operations group at a spacious manufacturing unit in Acton. The enterprise has reportedly been valued at £160m.

“I really feel we’ve got materially levelled up the expectations on the subject of personalisation,” stresses Mishreki.

“Beforehand, at greatest it means a quiz on an internet site and product suggestion. In our care we are actually making the ingredient and ripping up the inexperienced piece of paper [traditional prescription] and making a custom-made bottle and utilizing a laser to etch the prescription bottle each time. We all the time challenged ourselves on the best way to make it a dramatically higher buyer expertise.”

Learn Extra: ‘We have all grown up with radiators – underfloor heating is a no brainer’

Hailed as one of many UK’s quickest rising shopper well being manufacturers, Mishreki has moved from CEO to chairman and continues as Pores and skin + Me’s essential shareholder. He has since turned his consideration to a different startup, Life Provides, a refillable oral care model a number of years in the past which has shortly turned multimillion pound revenues.

“Both you stick at entrepreneurship and also you anticipate that issues will go improper for a lot of extra years or you possibly can cling your boots up. I selected the previous,” he says.

Management

All the pieces boils all the way down to the bar you set on day zero. It’s so vital to get these key early hires proper and to delay the launch of your small business to get these individuals proper.

We’ve now set the bar for expectations and personalisation on the subject of evaluating what you get at a pharmacy and the dearth of interplay you get via the NHS, as they only don’t have the capability.

Startup mentality

It’s important to work seven days every week constructing a startup and that is what I did. There may be a lot to get executed. If you’re working 9-5 5 days every week, you’ll in all probability run out of your cash or let a competitor beat you.

What retains you awake at night time?

Andy Grove, the previous Intel CEO, wrote Solely the Paranoid Survive which is all about an organization which didn’t suppose it might ever lose high spot. However it was underneath menace at one level after which pivoted the entire enterprise. The message is all the time be paranoid and I’m all the time considering what we are able to do to be even higher to enhance buyer expertise.

The specter of AI

What individuals actually worth is speaking to a human being. We use AI to make use of the enterprise extra effectively however the considered it changing what individuals actually worth looks like a stretch too far.

Learn extra:

Obtain the Yahoo Finance app, obtainable for Apple and Android

TAGGED:dermatology serviceJames Mishrekimarketing managementNorthumbria Universityskincare industry
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